ABSTRACT
Background: The objective of the study was to find out the personal hygiene status among boys residing in social welfare hostels by class and age and type of hostel.Methods: Cross sectional study, analytical study, social welfare hostels in Tirupati town of Andhra Pradesh. Participants was 524 boys. Statistical analysis are percentages and Chi-square test.Results: The prevalence of scabies was found to be significantly higher in those children with poor personal hygiene (35.7%) compared to average level (18.8%) and good (14.4%) of personal hygiene. The prevalence of other specific morbid conditions was found to be similar in all the three levels of personal hygiene and the differences were not statistically significant.Conclusions: The prevalence of scabies was found to be significantly higher in those children with poor personal hygiene compared to average level and good of personal hygiene. In view of higher proportion of children with poor level of personal hygiene of children in scheduled tribe hostel, there is a need to sensitize and give health education on personal hygiene related diseases and take necessary preventive steps and supervision by hostel staff especially in scheduled tribe hostel. Hand washing with soap can protect about one out of every three young children.
ABSTRACT
Background@#Chronic lymphocytic leukemia (CLL) is a heterogeneous disease, which is attributed to differences in the genetic characteristics of the leukemic clone. We studied the genomic profile of 52 treatment-naïve CLL patients. @*Methods@#Genetic analysis was performed by multiplex ligation-dependent probe amplification (MLPA) using the SALSA P038 Probemix (MRC Holland, Amsterdam), which contains probes for 2p (MYCN,ALK,REL), 6q, 8p (TNFRSF10A/B), 8q (EIF3H,MYC), 9p21 (CDKN2A/B), 10q (PTEN), 11q (ATM, RDX, PPP2R1B, CADM1), chromosome 12, 13q14 (RB1, DLEU1/2/7, KCNRG, MIR15A), 14q, 17p (TP53) and chromosome 19, and for NOTCH1 7541-7542delCT, SF3B1 K700E, and MYD88 L265P mutations. @*Results@#The median age was 65 years (male:female=2:1). The median hemoglobin, total leukocyte, and platelet counts were 12.4 g/dL, 57.7×10 9 /L, and 176.5×10 9 /L, respectively. At least one genetic abnormality was observed in 34 (65%) patients. The most common abnormality was del(13q14) (deleted DLEU2 and DLEU1/RB1 genes), which was observed in 22 (42%) cases, followed by trisomy 12 [7 (13%) cases]. Del(11q) (deleted ATM, RDX11/PPP2R1B-4) and del(17p) (deleted TP53) were present in 5 (10%) and 2 (4%) cases, respectively. 19p13.2 (CDKN2D-2) amplification and NOTCH1 mutation were found in one case each. @*Conclusion@#Genetic abnormalities are commonly (65%) observed in CLL patients. Del(13q), which is associated with DLEU2 andDLEU1/RB1 gene deletion, was the most common.Compared with other abnormalities, del(11q) and del(17p) patients presented with cytopenia and higher Binet stage, while those with del(13q14) had a longer time to first treatment.
ABSTRACT
Objective: This research investigated on in vitro ffree-radical scavenging property for the alcoholic extract from Pseudarthria viscida Linn. [Leguminosae]. Different antioxidant models of screening were employed
Material and methods: The alcoholic root extract of P. viscida was screened for free radical scavenging potential using 2, 2- azinobis- [3- ethyl-benzothiazoline- 6- sulphonate] [ABTS], 1, 1- diphenyl, 2- picrylhydrazyl [DPPH], superoxide and nitric oxide radicals
Results: Concentration dependent free radical scavenging activity was observed for the extract in which a concentration of 1000 micro g/ ml exhibited maximum scavenging activity against the radical cation, 2,2- azinobis- [3- ethylbenzothiazoline- 6- sulphonate] [99.41%], followed by superoxide radical using Riboflavin- Ethylene diamine tetra-acetic acid [97.60%] and the nitric oxide model [82.50%]. However, only moderate scavenging activity was observed with the 1, 1- diphenyl, 2- picryl hydrazyl radical [59.61%] at the same concentration
Conclusion: All the results of the in vitro antioxidant models of screening revealed the potent free-radical scavenging of the alcoholic root extract of Pseudarthria viscida Linn
ABSTRACT
To evaluate the antidiabetic effects of the alcoholic extract of leaves and stem of I. auamoclit employing a short term study. A short tem study was carried as a preliminary investigation to evaluate the antidiabetic effect of the alcoholic extract of leaves and stem of I. quamoclit and its normoglycemic and antihyperglycemic activity in streptozotocin [STZ[- nicotinamide induced non insulin-dependent diabetes mellitus rats using Glucose Tolerance Test t[GTT]. Graded doses [250 and 500 mg/kg] of the alcoholic root extract suspended in gum acacia were administered to normal and experimental diabetic rats. A significant fall in the blood glucose level of extract-treated animals was seen after 1 hour, indicating its hypoglycemic activity. Continuous blood glucose lowering activity was observed up to 4 hours of administration in normoglycemic and diabetic rats. The results were compared with those following the administration of standard oral hypoglycemic agent, glibenclamide. Administration of the alcoholic extract caused statistically significant decrease in the blood glucose levels of normal and diabetic rats as compared to the normal control and diabetic control groups respectively. Longer duration studies of Ipomoea quamoclit on chronic models may contribute toward the development of a potent antidiabetic drug
ABSTRACT
The methanol extracts of different medicinally important plants namely Datura metel, Thespesia populnea, Withania somnifera and Solatium surattense were tested against Bacillus subtilis, Pseudomonas aeruginosa, Escherichia coli and Proteus vulgaris by well-in agar method. The results revealed that T. populnea flower bud extract showed maximum zone of inhibition followed by D. metel, W. somnifera and S. surattense. When compared with individual extract, combination of extracts had good antibacterial activity against all tested pathogens